With the 15 years of being in existence, there have been several references to the Gene Logic databases in publications and in books. I am pretty amazed at the different kinds of research work being done with our databases and the services that we have been performing for our partners.
I will be annotating these in the coming few days so this is not an exhaustive list by any means.
*****************************************************************************
Articles in 2011
*****************************************************************************
1. Therapeutic Targeting the Loss of the Birt-Hogg-Dubé Suppressor Gene
Xiaohong Lu1, Wenbin Wei3, Janine Fenton1,2, Michael S. Nahorski1,2, Erzsebet Rabai2,4, Anne Reiman1,2, Laurence Seabra1,2, Zsuzsanna Nagy2,4, Farida Latif1,2,3 andEamonn R. Maher1,2,3
+Author Affiliations Authors’ Affiliations:1Medical and Molecular Genetics, School of Clinical and Experimental Medicine, 2Centre for Rare Diseases and Personalised Medicine, 3The Cancer Research UK Cancer Centre, and 4Division of Neuropharmacology and Neurobiology Section, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Corresponding Author: Eamonn R. Maher, Department of Medical and Molecular Genetics, School of Clinical and Experimental Medicine, University of Birmingham; Edgbaston, Birmingham B15 2TT
…….To identify candidate anticancer agents that might differentially affect cancer cell lines with differing
levels of FLCN expression, drugs with GI 50 positively correlated with the FLCN expression values
as measured using Affymetrix U133 array and U95 array by Gene Logic, Inc
*****************************************************************************
2. An antibody-drug conjugate targeting the endothelin B receptor for the treatment of melanoma.
Jyoti Asundi1, Chae Reed2, Jennifer Arca3, Krista McCutcheon4, Ronald Ferrando5, Suzanna Clark6, Elizabeth Luis7, Janet Tien8, Ron Firestein9, and Paul Polakis10,*
+Author Affiliations
1Cancer Targets, Genentech,Inc 2BioAnalytical Sciences, Genentech,Inc 3Translational Oncology, Genentech,Inc 4Research, Trellis Bioscience 5Pathology, Genentech, Inc 6Translational Oncology & Cancer Signaling, Genentech Inc 7Proetin Chemistry, Genentech Inc. 8Translation Oncology, Genentech, Inc. 9Pathology, Genentech 10Cancer Targets, Genentech, Inc
* Corresponding Author:Paul Polakis, Cancer Targets, Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, United States ppolakis@gene.com
*****************************************************************************
Robin J. Kleiman, Lida H. Kimmel, Susan E. Bove,Thomas A. Lanz,John F. Harms,Alison Romegialli,Kenneth S. Miller, Amy Willis, Shelley des Etages, Max Kuhn and Christopher J. Schmidt
+Author Affiliations
- Neuroscience Research Unit (R.J.K., L.H.K., S.E.B., T.A.L., J.F.H., A.R., A.W., C.J.S.), Genetically Modified Animals Unit (K.S.M.), Cardiovascular and Metabolic Disease Research Unit (S.d.E.), and Biostatistics Unit (M.K.), Pfizer Global Research and Development, Pfizer, Inc., Groton, Connecticut
- Address correspondence to:Dr. Robin J. Kleiman, Neuroscience Research Unit, Eastern Point Road, Pfizer Global Research and Development, Groton, CT 06379. E-mail:robin.j.kleiman@pfizer.comAffymetrix Chip Profiling and Data Analysis. RNA isolation and
hybridizations to mouse 430 2.0 whole genome Affymetrix (Santa Clara, CA) chips
were performed by GeneLogic (Gaithersburg, MD)
Hamid Saeed1, Basem M. Abdallah1, Nicholas Ditzel1, Philip Catala-Lehnen2, Weimin Qiu1, Michael Amling2, Moustapha Kassem1,3,*DOI: 10.1002/jbmr.349
Copyright © 2011 American Society for Bone and Mineral Research
*****************************************************************************
Articles in 2010
*****************************************************************************
*****************************************************************************
2. Mutated genes in cancer research
*****************************************************************************
*****************************************************************************
4. Molecular Biomarker Analyses Using Circulating Tumor Cells
*****************************************************************************
*****************************************************************************
*****************************************************************************
7. Research Gene expression profiles help identify the Tissue of Origin for metastatic brain cancers
*****************************************************************************
8. Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses
Catalina Lopez de Laraa1a2, Iris Jaitovich-Groismana1, Cristiana Cruceanua1, Firoza Mamdania1, Véronique Lebela1, Volodymyr Yerkoa1, Angus Becka3, L. Trevor Younga4, Guy Rouleaua5, Paul Grofa6, Martin Aldaa2a7 c2 and Gustavo Tureckia1 c1
this one references Genesis 2.0 , which is one of the most comprehensive gene expression analysis packages you can find. This allows users to completely view their data from Bioexpress or their own data and slice and dice the data in any manner they choose to. Very powerful indeed say most of the users who do use this product.
*****************************************************************************
Fokunang C. N.1*, Tembe-Fokunang E. A.1, Ngameni B.1, Barkwan S. S.2, Tomkins P. T.2,Asongalem E. A.1, Ngadjui B. T.1, Ngogang J. Y.1, Abena O. M. T.1and Asonganyi T.11Department of Pharmacy and African Pharmacotherapeutics, Faculty of Medicine and Biomedical Sciences,University of Yaoundé 1, P.O. Box 33032, Yaoundé, Centre Region, Cameroon.2Athlone Institute of Technology, Centre for Biopolymer and Bio–molecular Research, County Westmeath,Republic of Ireland.
this full length paper addresses the new high throughput means of assessing toxicity using toxicogenomics. Toxicogenomics investigate the changes in gene expression profile following exposure to a toxicant. This paper referes to the ToxExpress database created by Gene Logic and also looks at the field in general. Good reading material
*****************************************************************************
10 . State-of-the-art genomics approaches in toxicology
Paul Van Hummelena, b, ,
and Jennifer Sasakic
this paper addresses the new state of the art genomics techniques in the field of toxicology.
*****************************************************************************
11 A novel adipokine GM2AP impairs insulin signaling
Kiyoshi Higashia, ,
, Toshiyuki Mikamib, Toru Yamadab, Hitoshi Kawashimab, Toru Kimurab and Hideo Kanekoa
Articles in 2009
*****************************************************************************
1.
Articles in 2008
*****************************************************************************
Abstract :There is a need for new biomarkers to enable faster detection of adverse events due to drugs and disease processes. One would prefer biomarkers that are useful in multiple species (i.e., translational or bridging biomarkers) so that it would be possible to directly link responses between species and follow such injury in both preclinical and clinical settings. This chapter will explore some of the issues surrounding the use of pharmacogenomics to identify and qualify such biomarkers, and examples will be provided.
*****************************************************************************
2. In vivo predictive toxicogenomics.
Porter MW.
Department of Toxicogenomics, Gene Logic Inc., Gaithersburg, Maryland, USA.
Abstract
Reference databases consisting of large sample numbers and high-dimensional microarray data are now available for the investigation of adverse events in animal model systems such as the rat. This large volume of data, accompanied by appropriate study designs, compound and dose selection procedure, and minimization of technical and biological confounding effects, can yield successful predictive models for a variety of hypotheses. The process of training, validating, and implementing predictive models is cyclical and complex. This chapter highlights individual decisions that need to be made before, during, and after a model or set of models has been trained, with an emphasis on proper statistical methods and suitable interpretation of the results.
*****************************************************************************
Mendrick DL.
Department of Toxicogenomics, Gene Logic Inc., Gaithersburg, Maryland, USA.
Abstract
The field of toxicogenomics has been advancing during the past decade or so since its origin. Most pharmaceutical companies are using it in one or more ways to improve their productivity and supplement their classic toxicology studies. Acceptance of toxicogenomics will continue to grow as regulatory concerns are addressed, proof of concept studies are disseminated more fully, and internal case studies show value for the use of this new technology in concert with classic testing.
*****************************************************************************
Karanjawala ZE, Illei PB, Ashfaq R, Infante JR, Murphy K, Pandey A, Schulick R, Winter J, Sharma R, Maitra A, Goggins M, Hruban RH.The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231-2410, USA.
Abstract
The gene expression patterns of 24 surgically resected primary infiltrating ductal adenocarcinomas of the pancreas were compared with 18 non-neoplastic samples using the Affymetrix U133 Plus 2.0 Arrays and the Gene Logic GeneExpress Software System. Gene fragments from 4 genes (annexin A8, claudin 18, CXCL5, and S100 A2) were selected from the fragments found to be highly expressed in infiltrating adenocarcinomas when compared with normal tissues. The protein expression of these genes was examined using immunohistochemical labeling of tissue microarrays.
************************************************************************************
****************************************************************
Zarir E. Karanjawala, MD, PhD,* Peter B. Illei, MD,* Raheela Ashfaq, MD,† Jeffrey R. Infante, MD,*‡ Kathleen Murphy, PhD,* Akhilesh Pandey, MD, PhD,*‡§ Richard Schulick, MD,|| Jordan Winter, MD,|| Rajni Sharma, PhD,*Anirban Maitra, MBBS,*‡§ Michael Goggins, MD,*‡ and Ralph H. Hruban, MD*‡
****************************************************************
7. Empirical Bayes models for multiple probe type microarrays at the probe level
Magnus Åstrand, Petter Mostad and Mats Rudemo
*******************************************************************************
Articles in 2007
**********************************************************************
Ann Hess and Hari Iyer
**********************************************************************
Benjamin C. Lin, Manping Wang, Craig Blackmore and Luc R. Desnoyers 1
**********************************************************************
Bin Fan‡, Thomas D. Wu§, Wei Li‡ and Daniel Kirchhofer‡,1
*****************************************************************************
Xiaogang Ruana, Jinlian Wanga, Hui Lib, Rhoda E. Perozzic, and Edmund F. Perozzic,
*****************************************************************************
Articles in 2006
*************************************************
Simon Katz1, Rafael A Irizarry2, Xue Lin 3, Mark Tripputi1 and Mark W Porter1
*****************************************************************************
2.Complementary new approaches enable repositioning of failed drug candidates
Louis A Tartaglia†
*****************************************************************************
PAPAPETROPOULOS, SPIRIDON1; FFRENCH-MULLEN, JARLATH2; MCCORQUODALE, DONALD1; QIN, YUJING1; PABLO, JOHN1; MASH, DEBORAH C.1
*****************************************************************************
4.Uncovering potential biomarkers in ovarian carcinoma via biclustering of DNA microarray data
Tchagang,A.B. Tewfik,A.H. Skubitz,A.P.N. Skubitz,K.M.;
*****************************************************************************
Xi-De Wanga, Ching Ching Leowa, Jiping Zhab, Zhijun Tangc, Zora Modrusana, Freddy Radtked, Michel Aguete, Frederic J. de Sauvageaand Wei-Qiang Gaoa
*****************************************************************************
6. TTLL7 Is a Mammalian β-Tubulin Polyglutamylase Required for Growth of MAP2-positive Neurites
Koji Ikegami‡ , Masahiro Mukai ‡, Jun-ichi Tsuchida §, Robb L. Heier ¶, Grant R. MacGregor ¶ and Mitsutoshi Setou ‡ ∥ ** 1
D L Mendrick1, C Brazell2, E A Mansfield3, R Pietrusko4, I Barilero5, J Hackett6, S Stürzebecher7 and D Jacobson-Kram8
******************************************************************************
8.
James Leea, George I. Jalloa, Margaret B. Pennob, Kathleen L. Gabrielsonc, G. David Youngd, Randolph M. Johnsone, 1, Edward M. Gillise, 2, Charles Rampersaude, 2, Benjamin S. Carsona and Michael Guarnieria
*****************************************************************************
9.
Chang Liu1, Sujoy Ghosh1, David B. Searls1, Ann M. Saunders1, Jeffrey Cossman2 and Dr. Allen D. Roses1
*****************************************************************************
10.
Adolfo Sequeira, MSc; Fuad G. Gwadry, PhD; Jarlath M. H. ffrench-Mullen, PhD; Lilian Canetti; Yves Gingras, MSc; Robert A. Casero, Jr, PhD; Guy Rouleau, MD, PhD; Chawki Benkelfat, MD; Gustavo Turecki, MD, PhD
*****************************************************************************
Jennifer M. O’Toole1, Karen E. Rabenau1, Kerri Burns1, Dan Lu2, Venkat Mangalampalli3, Paul Balderes4, Nicole Covino4, Rajiv Bassi5, Marie Prewett5, Kimberly J. Gottfredsen6, Megan N. Thobe7, Yuan Cheng1, Yiwen Li5, Daniel J. Hicklin5, Zhenping Zhu2, Susan E. Waltz7, Michael J. Hayman6, Dale L. Ludwig3, and Daniel S. Pereira1
*****************************************************************************
Articles in 2005
Dr.Keith M Skubitz1,4, Edward Y Cheng2, Denis R Clohisy2, Roby C Thompson2 and Amy P. N Skubitz3
*****************************************************************************
2. Iterative Reconstruction of Transcriptional Regulatory Networks: An Algorithmic Approach
Christian L. Barrett, Bernhard O. Palsson*
*****************************************************************************
3.Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis
Michael Scott1, W. Glenn McCluggage2, Kenneth J. Hillan3, Peter A. Hall1, S.E. Hilary Russell1,*,†
*****************************************************************************
4.An Exploration of Affymetrix Probe-Set Intensities in Spike-In Experiments
Karla V. Ballman, Terry M. Therneau
******************************************************************************
5.
****************************************************************
Articles in 2004
****************************************************************
Keith M Skubitzac, Amy P.N Skubitzb
*****************************************************************************
2. Characterization of sarcomas by means of gene expression
Keith M Skubitzac, Amy P.N Skubitzb
*****************************************************************************
3. Gene expression in giant-celltumors
Keith M. Skubitzad, Edward Y. Chengbd,Denis R. Clohisybd,Roby C. Thompsonbd,Amy P.N. Skubitzcd
*****************************************************************************
Ching Ching Leow, Maria S. Romero, Sarajane Ross, Paul Polakis, and Wei-Qiang Gao
*****************************************************************************
Anne Marie Velasco, Kimberly A. Gillis, Yizheng Li, Eugene L. Brown, Tammy M. Sadler, Maria Achilleos, Lee M. Greenberger, Philip Frost, Wenlong Bai and Yixian Zhang
*****************************************************************************
GLORIA A PRESTON1, IWAO WAGA1, DAVID A ALCORTA, HITOSHI SASAI, WILLIAM E MUNGER, PAMELA SULLIVAN, BRIAN PHILLIPS, J CHARLES JENNETTE and RONALD J FALK
*****************************************************************************
J King
****************************************************************************
8.
Sung E Choe1,2, Michael Boutros6,1, Alan M Michelson1,2,3, George M Church1 and Marc S Halfon4,2,5*
************************************************************************************
Kris Freeman
*****************************************************************************
Articles in 2003
*****************************************************************************
William J Lemon*, Sandya Liyanarachchi† and Ming You*†
*****************************************************************************
2. Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry*, Bridget Hobbs, Francois Collin, Yasmin D. BeazerBarclay, Kristen J. Antonellis, Uwe Scherf and Terence P. Speed
*****************************************************************************
Grace L. Shen-Ong2, Yun Feng, and Dean A. Troyer
*****************************************************************************
Keith M. Skubitz M.D.1,*,†, Amy P. N. Skubitz Ph.D.2
*****************************************************************************
5. Heterogeneity of Variance in Gene Expression Microarray Data
Davidm. Rocke
*****************************************************************************
6. Highly Expressed Genes in Pancreatic Ductal Adenocarcinomas
Christine A. Iacobuzio-Donahue13,Raheela Ashfaq5, Anirban Maitra1, N. Volkan Adsay 6 , Grace L. Shen-Ong 7 , Karin Berg 1 , Michael A. Hollingsworth 8 , John L. Cameron 2 , Charles J. Yeo 2 , Scott E. Kern 13 , Michael Goggins 14 , and Ralph H. Hruban 13
*****************************************************************************
Toshio Higuchi‡§, Takuya Orita‡§, Setsuko Nakanishi‡, Ken Katsuya‡, Hirotaka Watanabe‡, Yoshiki Yamasaki‡, Iwao Waga‡, Toyomichi Nanayama¶, Yoshihisa Yamamoto¶, William Munger∥, Hong-Wei Sun∥, Ronald J. Falk**, J. Charles Jennette**,David A. Alcorta**, Huiping Li‡‡, Tadashi Yamamoto‡‡, Yutaka Saito‡ and Motonao Nakamura‡§§
Victor M. Markowitz
Articles in 2002
*****************************************************************************
George Webera, Edith Olaha, May S. Luia and Diana Tzenga
*****************************************************************************
4.
Articles in 2001
*****************************************************************************
*****************************************************************************
Barbara A. Eckman1,*, Anthony S. Kosky2 and Leonardo A. Laroco,Jr1
David Bailey, Edward Zanders, and Philip Dean
*****************************************************************************
9.
Articles in 2000
*****************************************************************************
6.Effects of c-erbB2 Overexpression on the Drug Sensitivities of Normal Human Mammary Epithelial Cells
Articles in 1999
*****************************************************************************
Prashar Y, Weissman SM.
*****************************************************************************
5.Protecting Genetic Privacy: Why It is So Hard to Do
Mark A. Rothstein
*****************************************************************************
Articles in 1998
*****************************************************************************
1. Manufacturing and quality control of plasmid-based gene expression systems.
Articles in 1997
*****************************************************************************
1. Chimeric receptors as gene switches
Victoria E Allgood,a and Eric M b
*****************************************************************************
Books
********************************************************************************
And it doesn’t stop at journal articles, there are several books that reference Gene Logic databases.
1. Application of toxicogenomics to cross-species extrapolation
*****************************************************************************
2. Analyzing microarray gene expression data
By Geoffrey J. McLachlan, Kim-Anh Do, Christophe Ambroise
*****************************************************************************
3. Applications of toxicogenomic technologies to predictive toxicology and risk assessment
*****************************************************************************
4. An introduction to toxicogenomics
*****************************************************************************
5. Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical …
Leave a Reply